Simvastatin decreases levodopa-induced dyskinesia in monkeys, but not in a randomized, placebo-controlled, multiple cross-over ("n-of-1") exploratory trial of simvastatin against levodopa-induced dyskinesia in Parkinson's disease patients.
Identifieur interne : 000C35 ( Main/Exploration ); précédent : 000C34; suivant : 000C36Simvastatin decreases levodopa-induced dyskinesia in monkeys, but not in a randomized, placebo-controlled, multiple cross-over ("n-of-1") exploratory trial of simvastatin against levodopa-induced dyskinesia in Parkinson's disease patients.
Auteurs : François Tison [France] ; Laurence Nègre-Pagès ; Wassilios G. Meissner ; Sandrine Dupouy ; Qin Li ; Marie-Laure Thiolat ; Thibaud Thiollier ; Monique Galitzky ; Fabienne Ory-Magne ; Agathe Milhet ; Laurent Marquine ; Umberto Spampinato ; Olivier Rascol ; Erwan BezardSource :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Aged, Animals, Antiparkinson Agents (adverse effects), Cross-Over Studies, Double-Blind Method, Dyskinesia, Drug-Induced (drug therapy), Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use), Levodopa (adverse effects), Macaca, Male, Middle Aged, Parkinson Disease (drug therapy), Parkinsonian Disorders (drug therapy), Simvastatin (therapeutic use).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- drug therapy : Dyskinesia, Drug-Induced, Parkinson Disease, Parkinsonian Disorders.
- chemical , therapeutic use : Hydroxymethylglutaryl-CoA Reductase Inhibitors, Simvastatin.
- Adult, Aged, Animals, Cross-Over Studies, Double-Blind Method, Humans, Macaca, Male, Middle Aged.
Abstract
Simvastatin may improve levodopa-induced dyskinesia through striatal Ras-extracellular signal-regulated kinase pathway modulation.
Url:
DOI: 10.1016/j.parkreldis.2012.12.003
PubMed: 23283428
Affiliations:
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Le document en format XML
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Meissner</name><name sortKey="Milhet, Agathe" sort="Milhet, Agathe" uniqKey="Milhet A" first="Agathe" last="Milhet">Agathe Milhet</name><name sortKey="Negre Pages, Laurence" sort="Negre Pages, Laurence" uniqKey="Negre Pages L" first="Laurence" last="Nègre-Pagès">Laurence Nègre-Pagès</name><name sortKey="Ory Magne, Fabienne" sort="Ory Magne, Fabienne" uniqKey="Ory Magne F" first="Fabienne" last="Ory-Magne">Fabienne Ory-Magne</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Spampinato, Umberto" sort="Spampinato, Umberto" uniqKey="Spampinato U" first="Umberto" last="Spampinato">Umberto Spampinato</name><name sortKey="Thiolat, Marie Laure" sort="Thiolat, Marie Laure" uniqKey="Thiolat M" first="Marie-Laure" last="Thiolat">Marie-Laure Thiolat</name><name sortKey="Thiollier, Thibaud" sort="Thiollier, Thibaud" uniqKey="Thiollier T" first="Thibaud" last="Thiollier">Thibaud Thiollier</name></noCountry><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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